Endocrine Abstracts

Introduction: Paraganglioma (PGL) develops from cells of the parasympathetic and sympathetic system. It usually manifests as a slow- growing and painless mass. PGL may be hereditary, benign, malignant, unilateral or bilateral tumors. In most cases PGL is located around the common carotid artery but may also be located within the middle ear or in the abdomen. Non functional retroperitoneal PGL are rare tumors, usually asymptomatic, and can attain big dimensions. Mutations in th...

Introduction: Thyroid disorders are common within the elderly population and are particularly challenging to diagnose and treat due to the presence of a wide variety of comorbidities. Graves’ ophtalmopathy remains a therapeutic predicament despite all progress made in understanding its pathogenesis, especially in the elderly population with severe presentation.Case presentation: We present the case of a 71-years-old female patient who was admitted i...

Introduction: Insulinoma is a rare pancreatic endocrine tumor derived from ß cells that secret insulin, which results in hypoglycemia. Most are benign and solitary. The median age at diagnosis is about 47 years. The age range for peak incidence is between 30 and 60 years and it is more prevalent in women. Diagnosis relies on clinical features along with laboratory tests and imaging. However, the nonspecific symptoms and small size of these tumors can lead to difficulties ...

Introduction: Morbidly obese patients raise many problems in therapeutic attitude, sometimes associating a cluster of obesity-related abnormalities: hypogonadotropic hypogonadism, metabolic syndrome, respiratory insufficiency, and high risk for cardiovascular disease. These afflictions can be reversed through weight loss, especially in young patients.Case presentation: We present the case of a 41 year old male patient, smoker, with morbid obesity (BMI =6...

Introduction: Endogenous Cushing’s syndrome (CS) is a rare disease associated with severe morbidity and increased mortality if untreated. Glucose metabolism is significantly altered in hypercortisolism.Objective: To retrospectively analyse the clinical presentation of a cohort of patients with endogenous CS and study the frequency of glucose metabolism abnormalities as opposed to other clinical signs and symptoms.Material and ...

Introduction: Testicular regression syndrome (TRS) or vanishing testis syndrome is a rare condition defined as the absence of testicular tissue in a genetic and phenotypic male. Rudimentary accessory structures can be present; in that case, the removal of all remnants is recommended.Case report: Male patient, 39 years old, had initially been evaluated at the age of 8 for persistent bilateral cryptorchidism. The medical documents are lacking except for a ...

Introduction: VD deficiency is associated with the atrophy of muscle fibres (predominantly type II). This leads to decreased muscle force and general physical performance.Objective: To analyse the relationship between the serum concentration of 25-hydroxy vitamin D (25OHD), balance and physical performance in women with VD deficiency and the effect of VD supplementation or treatment with a VD analog.Materials and methods: We analys...

Adrenal venous sampling (AVS) is regarded as the gold-standard for the study of lateralisation of primary aldosteronism (PA) after its biochemical diagnosis. After catheterisation of both adrenal veins, confirmed by ratio of cortisol concentration in each adrenal vein and peripheral vein (selectivity index (SI)), lateralization is accepted if aldosterone/cortisol (A/C) ratio between both adrenal veins is over 3–4 (lateralization index (LI)), particularly if non-dominant v...

Introduction: Hypothalamic obesity is defined as a syndrome of intractable weight gain as a result of hypothalamic lesions. Craniopharyngioma is responsible for more than half of the cases of hypothalamic obesity, but other pathologies can be implied. The syndrome can occur due to the tumour itself or its treatment (surgery or radiotherapy). Metformin is an antidiabetic drug that has also been used to treat nondiabetic obese patients, as it has been demonstrated to promote wei...

Differentiated thyroid carcinoma is the most common endocrine malignant tumor. Papillary carcinoma frequency in our country is 80% of thyroid neoplasia. Papillary thyroid carcinoma usually metastasizes to cervical lymph. Metastases to distant organs are rare and most often affect the lungs, liver and bones. Despite of its anatomical proximity, metastasis parotid have not been described in the existing papillary carcinomas literature. We report a case of parotid gland metastasi...